Yinsheng Wang Selected Research

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

12/2013	6-thioguanine induces mitochondrial dysfunction and oxidative DNA damage in acute lymphoblastic leukemia cells.
11/2011	Cyclophosphamide perturbs cytosine methylation in Jurkat-T cells through LSD1-mediated stabilization of DNMT1 protein.
3/2011	6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1.
11/2010	Quantitative proteomic analysis reveals the perturbation of multiple cellular pathways in jurkat-T cells induced by doxorubicin.
7/2010	LC-MS/MS coupled with stable isotope dilution method for the quantification of 6-thioguanine and S(6)-methylthioguanine in genomic DNA of human cancer cells treated with 6-thioguanine.
3/2009	6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.

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Yinsheng Wang Research Topics

Disease

62	Neoplasms (Cancer) 04/2024 - 11/2003
16	Melanoma (Melanoma, Malignant) 11/2021 - 04/2008
13	Breast Neoplasms (Breast Cancer) 11/2022 - 05/2004
9	Neoplasm Metastasis (Metastasis) 01/2023 - 01/2018
8	Colorectal Neoplasms (Colorectal Cancer) 01/2023 - 07/2010
6	Carcinogenesis 01/2023 - 11/2012
6	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2013 - 03/2009
5	Genomic Instability 01/2021 - 03/2016
4	Infections 01/2023 - 02/2016
4	Glioblastoma (Glioblastoma Multiforme) 01/2023 - 11/2018
4	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2022 - 01/2020
4	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 04/2005
3	COVID-19 01/2023 - 02/2021
3	Brain Neoplasms (Brain Tumor) 01/2023 - 12/2011
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 01/2021
3	Alzheimer Disease (Alzheimer's Disease) 10/2019 - 08/2007
3	Leukemia 01/2019 - 07/2010
3	Fanconi Anemia (Fanconi's Anemia) 01/2017 - 04/2014
3	Hepatolenticular Degeneration (Wilson's Disease) 03/2016 - 03/2011
3	Mitochondrial Diseases (Mitochondrial Disease) 11/2015 - 03/2012
2	Inflammation (Inflammations) 11/2023 - 12/2016
2	Stomach Neoplasms (Stomach Cancer) 01/2022 - 12/2021
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2012
2	Obesity 01/2020 - 09/2010
2	Wounds and Injuries (Trauma) 01/2020 - 01/2020
2	Osteosarcoma (Osteogenic Sarcoma) 08/2019 - 04/2014
2	Skin Neoplasms (Skin Cancer) 01/2019 - 01/2017
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2019 - 11/2010
2	Urinary Bladder Neoplasms (Bladder Cancer) 01/2017 - 01/2017
1	Seizures (Absence Seizure) 01/2023
1	Brain Diseases (Brain Disorder) 01/2023

Drug/Important Bio-Agent (IBA)

28	Proteins (Proteins, Gene)FDA Link 01/2023 - 05/2004
25	DNA (Deoxyribonucleic Acid)IBA 04/2024 - 11/2003
10	Phosphotransferases (Kinase)IBA 01/2023 - 11/2010
10	IsotopesIBA 01/2023 - 07/2010
9	RNA (Ribonucleic Acid)IBA 01/2023 - 02/2016
9	ArsenicIBA 01/2022 - 02/2010
7	Messenger RNA (mRNA)IBA 01/2023 - 01/2019
7	Monomeric GTP-Binding ProteinsIBA 11/2022 - 01/2018
7	ProteomeIBA 11/2022 - 11/2010
5	Amino Acids FDA Link 01/2023 - 12/2018
5	6-methyladenineIBA 01/2022 - 01/2020
4	Biomarkers (Surrogate Marker)IBA 12/2021 - 06/2006
4	Tamoxifen FDA LinkGeneric 01/2021 - 12/2018
4	Adenosine Triphosphate (ATP)IBA 01/2019 - 03/2012
4	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2016 - 08/2009
4	Thioguanine (Tioguanine)FDA Link 12/2013 - 03/2009
3	MethyltransferasesIBA 03/2023 - 01/2019
3	NucleosidesIBA 12/2021 - 06/2008
3	Protein Kinases (Protein Kinase)IBA 01/2021 - 01/2019
3	Estrogen ReceptorsIBA 01/2021 - 12/2018
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 07/2012
3	5-hydroxymethyl-2'-deoxycytidineIBA 11/2018 - 12/2011
3	IonsIBA 03/2016 - 08/2007
3	Methoxsalen (Oxsoralen)FDA Link 07/2013 - 04/2008
2	Adenine FDA LinkGeneric 01/2023 - 12/2021
2	Lysine (L-Lysine)FDA Link 01/2023 - 09/2007
2	TransferasesIBA 01/2023 - 01/2019
2	Peptides (Polypeptides)IBA 11/2022 - 11/2021
2	Antineoplastic Agents (Antineoplastics)IBA 01/2022 - 03/2011
2	Guanosine Triphosphate (GTP)IBA 11/2021 - 12/2018
2	GTP-Binding Proteins (G-Protein)IBA 11/2021 - 12/2018
2	InterferonsIBA 10/2021 - 02/2021
2	Viral ProteinsIBA 10/2021 - 02/2021
2	Adenylate KinaseIBA 01/2021 - 12/2020
2	DNA AdductsIBA 12/2020 - 11/2015
2	Matrix Metalloproteinases (MMPs)IBA 12/2020 - 01/2018
2	Secreted Matrix MetalloproteinasesIBA 01/2020 - 01/2019
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 01/2019
2	Imatinib Mesylate (Gleevec)FDA Link 01/2019 - 11/2010
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2019 - 01/2018
2	Arginine (L-Arginine)FDA Link 01/2019 - 01/2019
2	EnzymesIBA 01/2019 - 04/2014
2	5-methyldeoxycytidineIBA 11/2018 - 12/2011
2	EndonucleasesIBA 01/2018 - 01/2017
2	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 01/2018 - 07/2017
2	N3-carboxymethylthymidineIBA 07/2017 - 02/2009
2	Drinking WaterIBA 01/2017 - 01/2017
2	ThymidineIBA 11/2016 - 02/2009
2	CopperIBA 03/2016 - 03/2011
2	Membrane Proteins (Integral Membrane Proteins)IBA 10/2015 - 05/2008
2	Cisplatin (Platino)FDA LinkGeneric 04/2014 - 05/2013
2	5-hydroxymethylcytosineIBA 05/2013 - 12/2011
2	S 6 (S-6)IBA 11/2012 - 07/2010
2	CholesterolIBA 07/2012 - 09/2010
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2012 - 12/2011
2	CytosineIBA 11/2011 - 03/2009
2	MetalsIBA 03/2011 - 08/2007
2	Azathioprine (Imuran)FDA LinkGeneric 03/2011 - 07/2010
2	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 03/2011 - 07/2010
2	Ficusin (Psoralen)IBA 11/2008 - 04/2008
1	AlarminsIBA 11/2023
1	Retinoid X Receptor gammaIBA 11/2023
1	Serine Proteases (Serine Protease)IBA 01/2023
1	Angiotensin-Converting Enzyme 2IBA 01/2023
1	Coronavirus ReceptorsIBA 01/2023

Therapy/Procedure

14	Therapeutics 04/2024 - 11/2008
6	Drug Therapy (Chemotherapy) 01/2019 - 11/2010
5	Radiotherapy 11/2022 - 01/2015
2	Immunotherapy 01/2023 - 01/2020